Chemotherapy and Anemia
Overview: How blood is formed – erythropoiesis
To understand the link between chemotherapy and anemia, it is important to understand how blood cells are formed in normal circumstances.
The blood forming process starts from stem cells called hemocytoblasts. These cells are not differentiated meaning that they can develop into any of the types of bloods cells known. The first stage of differentiation occurs when two types of cells are formed. On one side common myeloid progenitor cells are formed while on the other, common lymphoid progenitor cells are formed. The myeloid progenitor cells are the precursors of what later differentiates into red blood cell (also known as erythrocytes), mast cell, myeloblasts and megakaryocytes. The myeloblasts further differentiate to form basophils, neutrophils, eosinophils and monocytes. The final process on the myeloblast side is when monocytes finally form macrophages. Meanwhile the megakaryocytes finally differentiate to thrombocytes. Read more...