Primary immunodeficiency occurs when part of a person’s immune system is missing or does not work correctly. The bodies of people with primary immunodeficiency can’t get rid of germs or protect themselves from new germs as well as they should.

Primary immunodeficiencies are inherited, meaning they are passed down from parents to children.

These immunodeficiencies range from very serious to very mild. The serious forms are often noticeable at birth or shortly thereafter. However, very mild forms may not be diagnosed until later in life, during adolescence or young adulthood.

The World Health Organization has identified more than 80 kinds of primary immunodeficiency diseases. But, the general category includes more than 100 diseases caused by an immune system that doesn’t function properly.

The warning sign of primary immunodeficiency may include:

• Eight or more new ear infections in one year
• Two or more serious sinus infections in one year
• Two or more months on antibiotics with little effect
• Two or more pneumonias within one year
• Failure of an infant to gain weight or grow normally
• Recurrent, deep skin or organ abscesses
• Recurrent thrush in mouth or elsewhere on skin, after age one
• Need for intravenous antibiotics to clear infections
• Two or more deep seated infections
• A family history of primary immunodeficiency

Also watch this video describing primary immunodeficiency.

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