Photo Project Sheds Light on Sickle Cell Anemia

12 Comments so far

1. Ron | 17 January 2008, 20:15

   A treatment made from natural plants is reported to greatly reduce the number and severity of SCD crises. It is Nicosan and is not available in the US at this time.

2. angel | 28 February 2008, 20:41

   So where can it be found?

3. Aslepius | 06 March 2008, 00:46

   Here is the latest on Nicosan/Niprisan a treatment for sickle cell anemia that has orphan drug status with both the FDA and E.U. The only thing holding it back is the pending investigational drug applications. It has completed phase IIb clinical trials.

   This drug could be obtained for use in the United States if a concerned group of patients would enlist the aid of a doctor to apply for the FDA’s expanded access program. It is a way for a non-toxic drug which is not approved to be made available for conditions where no approved drug is as safe. This drug shows a more than competitive success rate with none of the side effects of hydroxyurea.

   United Nations Economic Commission For Africa

   Book Of Abstracts

   Science With Africa Conference

   March 3-7, 2008

   page 30

   Evaluation of Niprisan (Herbal Medicine) for the Management of Sickle Cell
   Anaemia

   Charles Wambebe and Hadiza Khamofu, International Biomedical Research in Africa, Abuja,
   Nigeria, wambebe@yahoo.com, Joseph Okogun, Nathan Nasipuri and Karynius Gamaniel,
   National Institute for Pharmaceutical Research and Development, Abuja, Nigeria.

   About 70% of all sickle cell anemia (SCA) subjects reside in Africa, estimated at over 12 million. The prevalence of SCA is estimated at over 2% while infant mortality is about 8% and survival rate of SCA babies in rural areas by five years of age is about 20%. These statistics indicate that SCA is probably the most neglected (and sometimes forgotten by health authorities) serious public health disorder with serious mortality and morbidity rates in Africa. The objective was to undertake pre-clinical and clinical assessments of a herbal extract vis-à-vis management of sickle cell anemia using Good Laboratory Practice and Good Clinical Practice principles respectively. In Africa, there is no standard treatment for sickle cell anemia, only palliative management is generally available. In view of this situation, most
   SCA subjects use herbal medicines. NIPRISAN is a standardized extract from four medicinal/food plants: Piper guineenses seeds, Pterocarpus osun stem, Eugenia caryophyllum fruit and Sorghum bicolor leaves. Short term toxicity study indicated that NIPRISAN was safe in laboratory animals. Bio-activity guided fractionation show that vanillin and aromatic aldehydes may be the bioactive moieties. NIPRISAN reversed sickled red blood cells and
   protected them from being sickled when exposed to low oxygen tension. NIPRISAN dose- dependently delayed polymer formation of haemoglobin S. NIPRISAN induced 85% increased solubility of deoxy haemoglobin S. The in vivo efficacy study was undertaken at Children Hospital of Philadelphia, USA. Histological examination of lungs of control Tg transgenic mice carrying human sickle haemoglobin showed entrapment of massive numbers
   of sickled cells in alveolar capillaries. NIPRISAN significantly cleared the lungs of sickled cells. Furthermore, NIPRISAN induced profound effect on the survival time of Tg mice under hypoxic conditions (p

4. Aslepius | 20 March 2008, 16:33

   United Nations Economic Commission For Africa

   Book Of Abstracts

   Science With Africa Conference

   March 3-7, 2008

   page 30

   Evaluation of Niprisan (Herbal Medicine) for the Management of Sickle Cell
   Anaemia

   Charles Wambebe and Hadiza Khamofu, International Biomedical Research in Africa, Abuja,
   Nigeria, wambebe@yahoo.com, Joseph Okogun, Nathan Nasipuri and Karynius Gamaniel,
   National Institute for Pharmaceutical Research and Development, Abuja, Nigeria.

   About 70% of all sickle cell anemia (SCA) subjects reside in Africa, estimated at over 12 million. The prevalence of SCA is estimated at over 2% while infant mortality is about 8% and survival rate of SCA babies in rural areas by five years of age is about 20%. These statistics indicate that SCA is probably the most neglected (and sometimes forgotten by health authorities) serious public health disorder with serious mortality and morbidity rates in Africa. The objective was to undertake pre-clinical and clinical assessments of a herbal extract vis-à-vis management of sickle cell anemia using Good Laboratory Practice and Good Clinical Practice principles respectively. In Africa, there is no standard treatment for sickle cell anemia, only palliative management is generally available. In view of this situation, most
   SCA subjects use herbal medicines. NIPRISAN is a standardized extract from four medicinal/food plants: Piper guineenses seeds, Pterocarpus osun stem, Eugenia caryophyllum fruit and Sorghum bicolor leaves. Short term toxicity study indicated that NIPRISAN was safe in laboratory animals. Bio-activity guided fractionation show that vanillin and aromatic aldehydes may be the bioactive moieties. NIPRISAN reversed sickled red blood cells and
   protected them from being sickled when exposed to low oxygen tension. NIPRISAN dose- dependently delayed polymer formation of haemoglobin S. NIPRISAN induced 85% increased solubility of deoxy haemoglobin S. The in vivo efficacy study was undertaken at Children Hospital of Philadelphia, USA. Histological examination of lungs of control Tg transgenic mice carrying human sickle haemoglobin showed entrapment of massive numbers
   of sickled cells in alveolar capillaries. NIPRISAN significantly cleared the lungs of sickled cells. Furthermore, NIPRISAN induced profound effect on the survival time of Tg mice under hypoxic conditions (p

5. Ron | 14 April 2008, 19:50

   If you would like more information about this you can email me at goldrush2001 AT yahoo DOT com.

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8. smith | 18 August 2008, 06:17

   this is a very informative post, i was searching in google for anemia and came across this post my niece is suffering from chronic anemia, information mention in this article will greatly help me in offering her some advice.
   thank you
   Deborah

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11. oderas | 11 April 2011, 16:43

    we are a family who have just discoverd that our daughter who is now 12year was born with sickel cell dieases and we never knew until now.we are so worry and we ask for advice from other parents who have kids with this problem to help us understand more about its

12. shelton | 11 April 2011, 18:17

    wat if the mother have sickle cell disease and the father have the trait wat who the baby have?